We proposed a longitudinal study of intensive Vipassana meditation to investigate training-related changes in cognitive control, and to explore the relationship between cognitive control and growth in emotional well-being. The proposed data collection included participants undergoing one month of intensive meditative training at Spirit Rock Meditation Center between February and March 2009, as well as …
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Different approaches to emotion regulation: MBSR and CBT in the treatment of anxiety disorders
Few randomized controlled trials have directly compared the effects of mindfulness and acceptance-based MBSR and reappraisal-based CBT in the treatment of anxiety disorders. In the current study, we propose a randomized pilot study that compares MBSR and group CBT to enable a direct assessment of training in reappraisal and mindfulness-based emotion regulatory strategies, and their …
Effects of mindfulness meditation on cell aging processes
Chronic stress and major depressive disorder are associated with accelerated cellular aging, indicated by shortened telomeres in peripheral blood mononuclear cells (PBMCs). Psychological distress is also related to greater oxidative stress, a known cause of telomere shortening. The primary aim of the proposed research is to determine whether mindfulness meditation reduces oxidative stress and increases …
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Biopsychosocial assessment of a mindfulness-oriented treatment of alcohol dependence
This project will investigate the feasibility, acceptability, effect sizes, and therapeutic mechanisms of a novel, mindfulness-oriented cognitive therapy (MOCT) intervention for alcohol dependence, focusing on how attentional processes impact craving. A randomized control group design will be used, with 24 adult alcohol dependent persons per group. The MOCT arm will participate in 8 weekly 2 …
Efficacy of a 16-week mindfulness-based group for combat PTSD in recruiting veterans, and pilot effects on threat detection and emotion regulation neurocircuitry
We conducted a pilot study to investigate the feasibility, acceptability, and efficacy of an eight week “mindfulness-based” cognitive behavioral group therapy for chronic combat posttraumatic stress disorder (PTSD). Veterans seeking treatment at a Veterans Administration outpatient PTSD clinic (n=11) were enrolled in the study; five completed all eight sessions, three completed at least six sessions, …
Neural effects of mindfulness training on adults with ADD
In this proposal I seek to shed light on the behavioral and neural effects of mindfulness meditation training (MMT) on attention, memory, and inhibition in adults with attention deficit/hyperactive disorder (ADHD). Eligible subjects who reach criteria for ADHD as per evaluation by the Upenn center of cognitive therapy will attend an 8-week MMT course tailored …
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How does MBSR improve psychological functioning for cancer patients?
Receiving a diagnosis and undergoing cancer treatment is associated with high levels of emotional distress and related symptoms (e.g., anxiety, depression, and fatigue). MBSR has been consistently shown to reduce symptoms of stress and mood disturbance among cancer patients. Despite this, the question of “how” MBSR works has not been adequately addressed; it is not …
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Mindfulness training as treatment and mechanistic probe for drug addiction
Evidence points to the role of stress in the inception and maintenance of substance use disorders. Mindfulness training (MT) has shown promise in a number of stress-related maladies. However, no studies have compared MT to empirically-validated treatments for substance use disorders or assessed its impact on stress provocation. 36 individuals with alcohol and/or cocaine use …
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Using MBCT to prevent relapse to suicidality in patients suffering from ongoing depressive symptoms
A considerable number of those who suffer from depression develop a chronic course of the disorder in which symptoms remain over prolonged periods of time and risk for suicidality is significantly increased. Once patients have entered such a course, response to established treatments is significantly reduced. The aim of the current study was to test …
Neural Correlates of PTSD Prevention with MBSR in Iraq Veterans
With recently discharged veterans from Operation Iraqi Freedom (OIF) as our subjects, this study examines the neuroanatomical underpinnings as well as cognitive and perceptual biases associated with the progression of early onset Posttraumatic Stress Disorder (PTSD). We are comparing the efficacy of Mindfulness-Based Stress Reduction (MBSR; treatment) to Supportive Therapy (ST; control) as early interventions …
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